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1-Methylpiperazine → 2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-phenyl-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one | HCID 21991562 | — |
| 反応物 | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one | HCID 67214099 | — |
| 生成物 | 2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-phenyl-2H-pyridazin-3-one | HCID 21991426 | 77.1% |
反応手順
Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 77.1%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087606B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-40b31dad112f477da22ae7c8e274bb70 |
| 出典メモ | uspto-grants-2006_08 |