化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 3-Amino-4-picoline | HCID 137935 | — |
| 反応物 | 1-Chloro-2-isocyanato-2-methyl-propane | HCID 11040747 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea | HCID 68785605 | 97.1% |
反応手順
4-Methyl-pyridin-3-ylamine (1.98 g, 18.33 mmol) was added to solution of 1-chloro-2-isocyanato-2-methyl-propane (I-200c: 3 g, 20.40 mmol) in toluene (30 mL). The resulting mixture was stirred at room temperature for 3 days. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was filtered and the residue was dried to afford 4.3 g of the product (87.75% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045173E1 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b07c728c21cb48b78444794a121a8a1f |
| 出典メモ | uspto-grants-2014_09 |