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4-(Dimethylamino)phenylboronic acid → N-{4-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}-N,N-dimethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Dimethylamino)phenylboronic acid | HCID 2734344 | — |
| 反応物 | 4-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane | HCID 86649249 | — |
| 生成物 | N-{4-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}-N,N-dimethylamine | HCID 68781672 | — |
反応手順
The title compound was prepared from the product of Example 65A and 4-dimethylaminophenylboronic acid according to General Method B: 1H NMR (500 MHz, CDCl3) δ ppm 8.15 (s, 1 H), 8.03 (s, 1 H), 7.48 (d, 2 H), 7.06 (s, 1 H), 6.80 (d, 2 H), 3.73-3.35 (m, 7 H), 3.06-3.03 (m, 8 H), 2.27-2.17 (m, 3 H), 2.04-1.79 (m, 3 H), 1.88-1.77 (m, 3 H); LC-MS Method D (ESI+) m/z 349.0 (M+H)+, retention time 1.24 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846661B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-88692ce069404861affc19b25dd0f2ea |
| 出典メモ | uspto-grants-2014_09 |