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Pyridine → 1-benzyl-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 反応物 | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-benzyl-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9943096 | — |
反応手順
Similar to Example 1, equimolar amounts of benzylhydrazine dihydrochloride and 2-acetyl-3-oxo-butyric acid ethyl ester were combined in a solution of 50% pyridine in ethanol. The resulting oil was determined to be the named product by 1H-NMR (CDCl3, ppm): 1.35 t (3H); 2.44 s (3H); 2.45 s (3H); 4.38 a (2H); 5.25 s (2H); 7.08 d (2H); 7.29 m (3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087634B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-cdce1d85350340c0aefc14ad614d2d49 |
| 出典メモ | uspto-grants-2006_08 |