関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(Cyclopropylmethyl)piperazine | HCID 965875 | — |
| 反応物 | 4-(6-Chloro-3-pyridinyl)benzonitrile | HCID 49761821 | — |
| 生成物 | 4-(6-(4-Cyclopropylmethylpiperazin-1-yl)-pyridin-3-yl)-benzonitrile | HCID 58006667 | 43% |
反応手順
1-Cyclopropylmethyl-piperazine (13 g, 94 mmol) was mixed with 4-(6-cloro-pyridin-3-yl)benzonitrile (5 g, 23 mmol). The mixture was heated at 140° C. for 1.5 hours. The mixture was cooled to rt and purified by column chromatography (EtOAc:petrolether=1:1) on silica gel to give 2.7 g (43%) of 4-[6-(4-cylopropylmethyl-piperazin-1-yl)-pyridin-3-yl]-benzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846677B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-452190f306444fa498e29bad985dfcff |
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| 出典メモ | uspto-grants-2014_09 |
|---|
