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2-Methoxyethyl isothiocyanate → 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-N-[2-(methyloxy)ethyl]-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxyethyl isothiocyanate | HCID 123475 | — |
| 反応物 | 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-((tetrahydro-2H-pyran-4-yl)methyl)quinoline-3,4-diamine | HCID 70981155 | — |
| 生成物 | 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-N-[2-(methyloxy)ethyl]-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-2-amine | HCID 66571341 | 65% |
反応手順
From 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-((tetrahydro-2H-pyran-4-yl)methyl)quinoline-3,4-diamine (for a preparation see Intermediate 17) (70 mg) and 1-isothiocyanato-2-(methyloxy)ethane (50 mg) to give the title compound as beige solid (55 mg, 65%). LCMS (formate) Rt 0.68 min, MH+ 466
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846709B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-47b16875f9a54ad1b9cd92a1a2ad3995 |
| 出典メモ | uspto-grants-2014_09 |