関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| 反応物 | Cyclopropanecarboxamide | HCID 80376 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Ethyl 2-(2-cyclopropyloxazol-4-yl)acetate | HCID 86672106 | 50% |
反応手順
Ethyl 4-chloroacetoacetate (20.0 g, 122.0 mmol) was added to cyclopropanecarboxamide (3.52 g, 41.5 mmol) in toluene (100 mL) and 1,4-dioxane (100 mL). The mixture was refluxed at 120° C. for 17 hours then evaporated in vacuo. The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc) to afford the title compound as a white solid in 50% yield, 4.00 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846698B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-31cc3862d3244285a6a75e5c3f5b4c7c |
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| 出典メモ | uspto-grants-2014_09 |
|---|
