化工社化工社 化学情報印刷レポート · 研究参考用
Thiomorpholine 1,1-dioxide → Basmisanil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| 反応物 | 6-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68441898 | — |
| 生成物 | Basmisanil | HCID 57336276 | 55% |
反応手順
As described for example 105, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid (99 mg, 0.33 mmol) was converted, using thiomorpholine-S,S-dioxide instead of 2,2,2-trifluoroethylamine, to the title compound (73 mg, 55%) which was obtained as a white solid. MS: m/e=446.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846719B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-defa7aa03dd642089202778e3518a5cd |
| 出典メモ | uspto-grants-2014_09 |