化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 6-(2-Amino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-2-methyl-5-nitro-3H-pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine | HCID 19985785 | — |
| 反応物 | 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one | HCID 135617193 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-(2-Amino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-2-methyl-5-nitro-3H-pyrimidin-4-one | HCID 135671160 | — |
反応手順
In analogy to the procedure described in example 1c 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one as prepared in example 1a was treated with 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine [Ger. Offen. (1989), DE 3820775] in N,N-dimethylformamide in the presence of potassium carbonate at 110° C. to yield the title compound as yellow solid; m.p. >200° C.; MS: [M+H]+=323.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06369222B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-22707a29666845449681b670d21f45e1 |
| 出典メモ | uspto-grants-2002_04 |