化工社化工社 化学情報印刷レポート · 研究参考用
Water → 5-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1,3-Propanediol | HCID 10442 | — |
| 反応物 | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| 反応物 | 1-methyl-1H-imidazole-5-carbaldehyde | HCID 573592 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole | HCID 57919632 | — |
反応手順
To a solution of 1-methyl-1H-imidazole-5-carbaldehyde (2.9 g, 26.3 mmol) in toluene (20 mL) was added propane-1,3-diol (4.01 g, 52.7 mmol) and CSA (0.306 g, 1.317 mmol) and the reaction mixture was heated to reflux with azeotropic removal of the evolved water for 24 hours. The reaction mixture was cooled to RT, diluted with DCM and washed with NaHCO3 solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846927B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-e7428bd3e70b498dbb8013ec465cb6e1 |
| 出典メモ | uspto-grants-2014_09 |