化工社化工社 化学情報印刷レポート · 研究参考用
Hexamethylenetetramine → 5-Formylthiophene-2-Carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexamethylenetetramine | HCID 4101 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 5-Methylthiophene-2-carbonitrile | HCID 312733 | — |
| 反応物 | 5-(Bromomethyl)thiophene-2-carbonitrile | HCID 10560016 | — |
| 触媒 | Benzoyl Peroxide | HCID 7187 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-Formylthiophene-2-Carbonitrile | HCID 12280004 | 44.8% |
反応手順
8 g of 5-bromomethylthiophene-2-carbonitrile (prepared by brominating 5.7 g of 5-methylthiophene-2-carbonitrile and 8.42 g of N-bromosuccinimide in 68 ml of carbon tetrachloride under exposure to light and with the addition of 185 mg of benzoyl peroxide) is refluxed for 30 minutes in 35 ml of chloroform with 5.6 g of hexamethylenetetramine. The precipitated salt is suctioned off and refluxed in 30 ml of acetic acid and 30 ml of water for 2 hours. After extraction with ether, washing of the ether phase with water, drying, and evaporation, 2.43 g of 5-cyanothiophene-2-aldehyde is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05135937 |
| 出典データセット | uspto-grants-1992_08 |
| ORD ID | ord-f77561e20add459dad6676d9ede1dd19 |
| 出典メモ | uspto-grants-1992_08 |