化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1H-Indazole-3-carboxylic acid, 1-methyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 1-methyl-1H-indazole-3-carboxylate | HCID 13900574 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1H-Indazole-3-carboxylic acid, 1-methyl- | HCID 689105 | 92% |
反応手順
A solution of 1-methylindazole-3-carboxylic acid, methyl ester (1.00 g, 0.0053 mole; was stirred in a mixture of methanol (10 ml)/2N NaOH solution (120 ml) at reflux temperature for 2 hours. After cooling, the mixture was diluted with water (100 ml) and acidified with 6N HCl solution. The white solid that formed was collected by filtration and dried under ambient conditions for 6 days to give 0.86 g (92% yield) of the product; mp 215°-216° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05137895 |
| 出典データセット | uspto-grants-1992_08 |
| ORD ID | ord-43754bed1c39445a92a6663e5e0e6ce6 |
| 出典メモ | uspto-grants-1992_08 |