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HRID 85145作成日：2026年10月24日
4-Fluoro-2-(trifluoromethyl)benzaldehyde → 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester
https://huagongshe.com/ja/reaction/85145
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluoro-2-(trifluoromethyl)benzaldehyde | HCID 522940 | — |
| 反応物 | ethyl 4,5-diaminonicotinate | HCID 58278930 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Nitrobenzene | HCID 7416 | — |
| 生成物 | 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester | HCID 67203080 | 39% |
反応手順
A mixture containing ethyl 4,5-diaminonicotinate (79; 0.9 g, 5 mmol) and 4-fluoro-2-(trifluoromethyl)benzaldehyde (82; 1.0 g, 5.2 mmol) in nitrobenzene (50 mL) was stirred at 220° C. for 18 h. Upon cooling to room temperature, the reaction mixture was diluted with ether. The resulting solids were collected by filtration, washed with ether, and dried to provide 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester 83 (600 mg, 39%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846947B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-b328a1b49fd64a988b49f4986f52c821 |
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| 出典メモ | uspto-grants-2014_09 |
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