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2,3-Diaminobenzoic acid → 2-(2-(difluoromethyl)-4-(2-morpholinoethoxy)phenyl)-1H-benzo[d]imidazole-7-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| 反応物 | 2-(Difluoromethyl)-4-(2-morpholinoethoxy)benzaldehyde | HCID 83854627 | — |
| 生成物 | 2-(2-(difluoromethyl)-4-(2-morpholinoethoxy)phenyl)-1H-benzo[d]imidazole-7-carboxylic acid | HCID 178524245 | 48% |
反応手順
2,3-Diaminobenzoic acid (1; 222 mg, 1.5 mmol) and the corresponding 2-(difluoromethyl)-4-(2-morpholinoethoxy)benzaldehyde 124 were subjected to the same general procedure detailed above to afford 2-(2-(difluoromethyl)-4-(2-morpholinoethoxy)phenyl)-1H-benzo[d]imidazole-7-carboxylic acid 125 (300 mg, 48%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846947B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0a317f28990942a3b134fb224e52afbd |
| 出典メモ | uspto-grants-2014_09 |