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2,3-Diaminobenzoic acid → 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| 反応物 | 2-Methylpyridine-3-carbaldehyde | HCID 11083881 | — |
| 生成物 | 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67201388 | — |
反応手順
2-Methylnicotinaldehyde (149; 2.18 g, 18 mmol) was subjected to the standard conditions used to prepare substituted benzimidazoles by reaction with 2,3-diaminobenzoic acid 1. The desired product, 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid 150, was obtained by purification using chromatography, followed by crystallization from EtOAc (0.43 g, 11%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846947B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-a9508b06c04a4fd9872ce6c2ef014089 |
| 出典メモ | uspto-grants-2014_09 |