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Methyl vinyl ketone → F2184-0181
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl vinyl ketone | HCID 6570 | — |
| 反応物 | Phthalimide | HCID 6809 | — |
| 反応物 | 2-Aminopyridine | HCID 10439 | — |
| 反応物 | 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione | HCID 3759744 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | F2184-0181 | HCID 1531269 | 96.6% |
| 生成物 | 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione | HCID 3759744 | — |
反応手順
2-(4-Bromo-3-oxo-butyl)-isoindole-1,3-dione is prepared by condensation of but-1-en-3-one with phthalimide followed by bromination according to known procedures (J. Med. Chem., 35:3239, 1992. A solution of 2-(4-bromo-3-oxo-butyl)-isoindole-1,3-dione (8.9 g, 30.06 mmol) and 2-aminopyridine (2.8 g, 29.75 mmol) in ethanol is heated at reflux for 4 hours. The mixture is cooled to room temperature and concentrated. The residue is purified by chromatography (silica gel, dichloromethane/ethanol 95:5); to give 4.23 g of 2-[2-(imidazo[1,2-a]pyridin-2-yl)ethyl]-isoindole-1,3-dione (49%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07253181B2 |
| 出典データセット | uspto-grants-2007_08 |
| ORD ID | ord-5cf52dd38b4f435ea3f1991362cf0eef |
| 出典メモ | uspto-grants-2007_08 |