関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | 4-Methoxypyridine | HCID 69278 | — |
| 反応物 | HCID 178418473 | HCID 178418473 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-Cbz-6-allyl-2,3-dihydro-1H-pyridin-4-one | HCID 22015691 | — |
反応手順
To a solution of 4-methoxypyridine (50 mL, 0.492 mol) in toluene (1 L) is added benzyl chloroformate (70.3 mL, 0.492 mol) at 0° C. The resulting mixture is stirred at 0° C. for 30 minutes then cooled to −75° C. and allyl magnesium chloride (295.5 mL, 0.591 mol) is added. The solution is held at −75° C. for 4 hours and allowed to warm to 0° C. at which point a solution of 20% HCl is added to quench the reaction. The organic layer is isolated and purified over silica gel to yield the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087759B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-f6db860dab31434dab410e8efec808ed |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
