Phenethylamine, m-trifluoromethyl- → (2,2-Dimethyl-benzo[1,3]dioxol-5-ylmethyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amine

関与物質

反応手順

The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 84 mg of 2,2-dimethyl-benzo[1,3]dioxole-5-carbaldehyde (0.47 mmol), 89 mg of 2-(3-trifluoromethylphenyl)-ethylamine (0.47 mmol) and 27 mg of sodium borohydride (0.71 mmol). The isolated colorless semisolid (137 mg, 83%) was used in the following step without further purification. 1H NMR (CDCl3, 300 MHz): δ 1.66 (s, 6H), 2.89 (m, 4H), 3.70 (s, 2H), 6.68 (m, 3H), 7.39 (m, 2H), 7.46 (m, 2H).

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