関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diethyl bromomalonate | HCID 69637 | — |
| 反応物 | 8-Oxa-3-azabicyclo[3.2.1]octane | HCID 12069231 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Diethyl 2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)malonate | HCID 21983519 | — |
反応手順
4.72 g (19.8 mmol) of diethyl 2-bromomalonate are introduced into 30 ml of acetonitrile. Then 3.82 g (27.7 mmol) of potassium carbonate and 2.46 g (21.7 mmol) of 8-oxa-3-azabicyclo[3.2.1]octane from step 4 are added. The suspension is stirred at 50° C. overnight. This is followed by filtration with suction and evaporation of the filtrate to dryness in a rotary evaporator. The residue is employed without further purification in the next stage.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091198B1 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-e6c92f751d374d10a3c43575d67b3af8 |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
