関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Venlafaxine | HCID 5656 | — |
| 反応物 | 1-Dodecanethiol | HCID 8195 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 生成物 | Desvenlafaxine | HCID 125017 | — |
反応手順
Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C. The methanol is distilled off and the solution is stirred for 2 hours at 190° C. Then the temperature is lowered, 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07154001B2 |
|---|
| 出典データセット | uspto-grants-2006_12 |
|---|
| ORD ID | ord-014df8edd2784c42bdd24c0f8e68eb7e |
|---|
| 出典メモ | uspto-grants-2006_12 |
|---|
