化工社化工社 化学情報印刷レポート · 研究参考用
Acetonitrile → [2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-thiophen-3-yl-methylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-methylthiophen-3-amine | HCID 642344 | — |
| 反応物 | 3-[3-(2-Bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole | HCID 21983582 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | [2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-thiophen-3-yl-methylamine | HCID 69652881 | — |
反応手順
The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, thiophen-3-yl-methylamine (prepared according to Synthetic Metals, 26 (1988)153–168) and acetonitrile essentially as described above in example 18, except that water (0.40 mL) is added to the reaction mixture before heating. Purity by LC/MS (APCI)=100%, [M+H]+=357.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091199B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-9c632d1f03ef4ea1ad693653be4afc16 |
| 出典メモ | uspto-grants-2006_08 |