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tert-Butyl Formate → Tert-butyl 4-(5-cyanopyridin-2-yl)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl Formate | HCID 61207 | — |
| 反応物 | 6-Bromopyridine-3-carbonitrile | HCID 5005718 | — |
| 反応物 | Tert-butyl 4-iodopiperidine-1-carboxylate | HCID 10892302 | — |
| 生成物 | Tert-butyl 4-(5-cyanopyridin-2-yl)piperidine-1-carboxylate | HCID 69453251 | 27% |
反応手順
This compound was synthesized from 6-bromonicotinonitrile and tert-butyl 4-iodopiperidine-1-carboxylate as described for example 49 step 1 (150 mg, yield 27%). 1H NMR (400 MHz, CDCl3) δ 8.82 (d, J=2.0 Hz, 1H), 7.91 (dd, J=8.2 Hz, 2.1 Hz, 1H), 7.30 (d, J=8.0 Hz, 1H), 4.28 (m, 2H), 2.97-2.81 (m, 3H), 1.91 (m, 2H), 1.78-1.67 (m, 2H), 1.48 (s, 9H). MS (ESI) m/z: Calculated for C16H21N3O2: 287.16. found: 188.2 (M+H-Boc)+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08981084B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-e30fa4a8e33a451eadbef6c90ecba643 |
| 出典メモ | uspto-grants-2015_03 |