関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diphenyl Ether | HCID 7583 | — |
| 反応物 | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 5373687 | 71% |
反応手順
A solution of diphenyl ether was heated to 250° C. and the product of Example 7a (2.50 g, 9.0 mmol) was added in several small portions over a period of about 5 min then heated at 250° C. for 30 min. After cooling to room temperature diluted with hexane. The resulting solid was filtered and was dried under vacuum giving the title compound as a tan solid (1.47 g, 71%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08236950B2 |
|---|
| 出典データセット | uspto-grants-2012_08 |
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| ORD ID | ord-b64616e25b764667a9e4403f93c7b521 |
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| 出典メモ | uspto-grants-2012_08 |
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