化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → 5-bromo-N-methylpyrimidine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Methyl 5-bromopyrimidine-2-carboxylate | HCID 45790831 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-bromo-N-methylpyrimidine-2-carboxamide | HCID 66759926 | — |
反応手順
To a solution of 5-bromopyrimidine-2-carboxylic acid methyl ester (5.0 g, 23.0 mmol) in THF (10 mL) was added 8 N solution of methyl amine in ethanol (11.5 mL). The reaction mixture was heated 20 min in a microwave oven, cooled down to room temperature and concentrated under pressure to give 5 g of 5-bromo-N-methylpyrimidine-2-carboxamide as a solid LCMS: 216, 218 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08252793B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-b99a6a2d4fbe41318e0cca3fe6f2fac2 |
| 出典メモ | uspto-grants-2012_08 |