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N-(4-Methoxybenzyl)pyridin-2-amine → 6-Chloro-8-((4-methoxybenzyl)(2-pyridinyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(4-Methoxybenzyl)pyridin-2-amine | HCID 97452 | — |
| 反応物 | 6-Chloro-8-((5-methoxypyridin-2-yl)(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 86641380 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 6-Chloro-8-((4-methoxybenzyl)(2-pyridinyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile | HCID 86641381 | — |
反応手順
8A was prepared from a mixture of 1F and N-(4-methoxybenzyl)pyridin-2-amine following the procedure employed for the preparation of 5B. HPLC: Rt=3.881 min. (YMC S5 ODS 4.6×50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min gradient, monitored at 220 nm). MS (ES): m/z=391.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08252795B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-568bfde78c054bbd812f01f105213689 |
| 出典メモ | uspto-grants-2012_08 |