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Propylene Oxide → (6-Benzyloxy-indol-1-yl)-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propylene Oxide | HCID 6378 | — |
| 反応物 | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| 生成物 | (6-Benzyloxy-indol-1-yl)-propan-2-ol | HCID 22247173 | — |
反応手順
6-Benzyloxyindole (1) (Batcho and Leimgruber, Organic Syntheses, Collective Vol. 7, p. 34 (1990)) is reacted with (±)-propylene oxide and a base in an organic solvent to yield (±)-1-(2-hydroxypropyl)-6-benzyloxyindole (2). Preferably the base is sodium hydride and the solvent is tetrahydrofuran. The temperature is 0° C. to 25° C., preferably about 10° C. Preferably an inert atmosphere, e.g., nitrogen or argon, is maintained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06998489B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-c9269fc643d04eaf8aacfbc51d040769 |
| 出典メモ | uspto-grants-2006_02 |