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Lithium Hydroxide → HCID 10119620、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | 3-Methylglutaric anhydride | HCID 77828 | — |
| 反応物 | 1-(2-Aminophenoxy)-3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]-2-propanol | HCID 9869936 | — |
| 反応物 | Oxolane--water (1/1) | HCID 21881883 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 10119620 | HCID 10119620 | — |
反応手順
1-(2-aminophenoxy)-3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]-2-propanol (75 uL, 0.2M/NMP) was mixed with 3-methyl glutaric anhydride (3 eq, 225 uL 0.2M /NMP) to get a product containing both esther and amide. After evaporation of the mixture it was treated with 3 eq 0.5M LiOH in (THF/water 1:4) for two hours at 80° C. to hydrolyse the esther. The reaction mixture was diluted with more water (2 mL) and the desired product was extracted with 5×500 uL EtOAc which was evaporated to dryness.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07005439B2 |
| 出典データセット | uspto-grants-2006_02 |
| ORD ID | ord-5ec1299173da45a9b8e12c6aa3d84e9f |
| 出典メモ | uspto-grants-2006_02 |