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Calcium Carbonate → Ethyl 1-cyano-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | Ethyl 2-bromo-2-cyanoacetate | HCID 14469 | — |
| 反応物 | 1,3-Pentadiene, 1,1-dichloro-4-methyl- | HCID 108746 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 1-cyano-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylate | HCID 12898169 | 56.5% |
反応手順
A mixture of 1,1-dichloro-4-methylpenta-1,3-diene (30.2 parts) and ethyl bromocyanoacetate (19.2 parts) is heated in ethanol (100 parts by volume) at 77°-80° C. for 6 hours in the presence of cupric chloride (1.34 parts) and calcium carbonate (10 parts). The crude ethyl 1-cyano-3-(2',2'-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylate is isolated as described in Examples 13-24. The product has a strength of 61.0% and a cis-cyano/trans-cyano ratio of 85.2:14.8. The yield is 56.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04284582 |
| 出典データセット | uspto-grants-1981_08 |
| ORD ID | ord-2c34f3400e8346b3a76b874835d0d7ba |
| 出典メモ | uspto-grants-1981_08 |