化工社化工社 化学情報印刷レポート · 研究参考用
Methoxyacetic Acid → 5-(Methoxymethyl)-1,3,4-thiadiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methoxyacetic Acid | HCID 12251 | — |
| 反応物 | Thiosemicarbazide | HCID 2723789 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(Methoxymethyl)-1,3,4-thiadiazol-2-amine | HCID 660844 | — |
反応手順
Addition of phosphonyl chloride to a mixture of thiosemicarbazide and methoxyacetic acid at 60°-95° and working up of the product yields 5-amino-2-methoxymethyl-(1,3,4)-thiadiazole, m.p. 177°-179° (from water). When this compound is diazotised and treated with cuprous bromide 5-bromo-2-methoxymethyl-(1,3,4)-thiadiazole results and reaction of this bromo compound with zinc dust in acetic acid at room temperature yields 2-methoxymethyl-(1,3,4)-thiadiazole, m.p. 30.5°-32°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04284640 |
| 出典データセット | uspto-grants-1981_08 |
| ORD ID | ord-8c26dff5f7bc496696e4daaa46a79d7e |
| 出典メモ | uspto-grants-1981_08 |