化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → Diethyl 3-methoxyphenylmethoxymethylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Methoxybenzyl alcohol | HCID 81437 | — |
| 反応物 | (Diethoxyphosphoryl)methyl trifluoromethanesulfonate | HCID 11833487 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diethyl 3-methoxyphenylmethoxymethylphosphonate | HCID 57457789 | — |
反応手順
A mixture of 3-methoxybenzyl alcohol (1 mmol) and sodium hydride (1.5 mmol) in 5 mL DMF was stirred at rt for 1 h and then added via cannula to a solution of diethylphosphonomethyl triflate (1 mmol) in 5 mL of DMF and the resulting mixture stirred at rt for 16 h. Extraction and chromatography provided diethyl 3-methoxyphenylmethoxymethylphosphonate as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06919322B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-00768cb80cee40e1a1d29555ffc8d90e |
| 出典メモ | uspto-grants-2005_07 |