関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 2-azidoacetate | HCID 4020482 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 4-(Benzyloxy)-3-nitrobenzaldehyde | HCID 7023554 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl(Z)-2-azido-3-(4-benzyloxy-3-nitrophenyl)acrylate | HCID 86598196 | 59% |
反応手順
Under argon, to a sodium methoxide solution (prepared from 2.5 g (108.7 mmol) of sodium and 70 ml of methanol) a mixture of 6.1 g (23.7 mmol) of 4-benzyloxy-3-nitrobenzaldehyde and 11.2 g (97.3 mmol) of methyl azidoacetate in 100 ml of methanol is added at 0° C. The mixture is stirred at 0° C. for 5 h, then diluted with 350 ml of water, the precipitated crystals were filtered off, washed with water and dried to yield 4.93 g (59%) of the title compound. Mp.: 95-96° C. (water).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07361670B2 |
|---|
| 出典データセット | uspto-grants-2008_04 |
|---|
| ORD ID | ord-ac7f5d9bb0824607a8cda1dddaf7a218 |
|---|
| 出典メモ | uspto-grants-2008_04 |
|---|
