Phenacyl bromide → 6-Fluoro-2-oxo-1-(2-oxo-2-phenyl-ethyl)-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carboxylic Acid Ethyl Ester

関与物質

反応手順

This compound was prepared from 6-fluoro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester (80) and 2-bromoacetophenone according to General Procedure B. Yield 293 mg (38%), MP 262° C.; 1H-NMR (DMSO-d6): δ 1.29 (t, J=7.2 Hz, 3H), 3.19 (m, 4H), 3.92 (m, 4H), 4.32 (q, J=7.2 Hz, 2H), 5.88 (s, 2H), 7.16 (dd, J=3.6, 4.8 Hz, 1H), 7.47 (dd, J=1.2, 3.6 Hz, 1H), 7.61 (m, 2H), 7.72 (m, 1H), 7.81 (d, J=4.8 Hz, 1H), 8.11 (m, 2H), 8.18 (dd, J=2.8, 8.8 Hz, 1H), 8.65 (d, J=2.8 Hz, 1H); EIMS: 549 (M+1). Anal. (C28H25FN4O5S) C, H, N.

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