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Chloroform → 3-[4-(8-Cyclohexyloctylamino)benzoyl]carboxythiazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Timonacic | HCID 9934 | — |
| 反応物 | Ethyl thiazolidine-4-carboxylate | HCID 103574 | — |
| 反応物 | p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride | HCID 20475769 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 溶媒 | Acetone sodium bicarbonate | HCID 86737261 | — |
| 生成物 | 3-[4-(8-Cyclohexyloctylamino)benzoyl]carboxythiazolidine | HCID 20475813 | — |
反応手順
One-tenth mole of 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile. By means of the alkaline hydrolysis method of Example 1, the ethyl ester is converted to the subject carboxylic acid. This acid is also prepared using the procedure of this Example except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04227014 |
| 出典データセット | uspto-grants-1980_10 |
| ORD ID | ord-b7964c11b5f04165a73d39ad8d1f8a19 |
| 出典メモ | uspto-grants-1980_10 |