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Piperazine → 5-(Benzyloxy)-2-(piperazin-1-yl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Pyrimidine | HCID 9260 | — |
| 反応物 | 2-Methylsulfonyl-5-phenylmethoxypyrimidine | HCID 2802902 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-(Benzyloxy)-2-(piperazin-1-yl)pyrimidine | HCID 2802901 | 42% |
反応手順
A mixture of the pyrimidine prepared in (a) above (24.5 g, 0.09 mole), piperazine (77.5 g, 0.9 mole), and toluene (160 mL) was heated at 150° C. in a stainless steel omb for 22 hr. The reaction mixture was filtered, concentrated in vacuo, and the residue crystallized from Skelly B to give 10.15 g (42%) off-white solid, m.p. 94°-97° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04423049 |
| 出典データセット | uspto-grants-1983_12 |
| ORD ID | ord-d07aaf8960c447c1a3ce0bfacd8a1b96 |
| 出典メモ | uspto-grants-1983_12 |