関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(Tri-n-butylstannyl)thiophene | HCID 2779373 | — |
| 反応物 | 1-(5-Bromopyridin-3-yl)-4-methylpiperazine | HCID 53485314 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 1-Methyl-4-(5-thiophen-2-yl-pyridin-3-yl)-piperazine | HCID 22632288 | — |
反応手順
To a vial was added 1-(5-bromo-pyridin-3-yl)-4-methyl-piperazine (47 mg, 0.13 mmol), Pd(PPh3)4 (34 mg), 2-thienyltributylstannane (67 mg, 0.15 mmol) and dioxane (1 mL). The resulting mixture was heated at 100° C. for 24 hrs. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08022209B2 |
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| 出典データセット | uspto-grants-2011_09 |
|---|
| ORD ID | ord-f590971f92df40c184810059889b07ef |
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| 出典メモ | uspto-grants-2011_09 |
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