関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Zytron | HCID 9299 | — |
| 反応物 | Diketene | HCID 12661 | — |
| 反応物 | (S)-1-(4-Methoxyphenyl)ethylamine | HCID 793467 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 86624412 | HCID 86624412 | — |
反応手順
To a solution of (S)-1-(4-methoxy-phenyl)-ethylamine (25 g) in dichloromethane (60 mL) was added TEA (20 g) and DMPA (200 mg). Then a solution of 4-methylene-oxetan-2-one (16.7 g) in dichloromethane (60 ml) was added over a period of 30 minutes and then stirred at 20° C. for 18 h. The mixture was washed with 1M HCl, aq. NaHCO3 and aq. NaCl. The organic layer was dried (MgSO4), filtered and concentrated in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08022218B2 |
|---|
| 出典データセット | uspto-grants-2011_09 |
|---|
| ORD ID | ord-fdd2daeea4e04186afc19c09f929978c |
|---|
| 出典メモ | uspto-grants-2011_09 |
|---|
