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Methyl iodide → 1-(6-Bromo-7-methoxy-2-benzothiazolyl)-3-ethyl-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethylurea | HCID 21985595 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(6-Bromo-7-methoxy-2-benzothiazolyl)-3-ethyl-urea | HCID 21985520 | 2% |
反応手順
A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and iodomethane in DMF was reacted to give 0.0034 g (2%) of the desired compound 10. 1H NMR (DMSO) δ 10.88 (br s, 1H, NH), 7.55 (d, 1H, J=8.5 Hz, ArH), 7.33 (d, 1H, J=8.5 Hz, ArH), 6.82 (br s, 1H, NH), 3.93 (s, 3H, CH3), 3.18 (m, 2H, CH2), 1.09 (t, 3H, J=7.2 Hz, CH3); LC/MS 330 (MH+); RP-HPLC RT 3.04 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091227B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-12cf03b2e2304f0c877426f44e1029ac |
| 出典メモ | uspto-grants-2006_08 |