化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide dimethyl acetal → 1-(4-Chlorophenyl)-3-(dimethylamino)-2-phenylprop-2-en-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 4'-Chloro-2-phenylacetophenone | HCID 233840 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(4-Chlorophenyl)-3-(dimethylamino)-2-phenylprop-2-en-1-one | HCID 69416172 | 100% |
反応手順
A solution of benzyl 4-chlorophenyl ketone (10.0 g, 43.3 mmol) and dimethylformamide dimethylacetal (23 mL, 173 mmol) in DMF (125 mL) was heated at 75° C. for 20 h. The volatiles were removed in vacuo to provide 3-dimethylamino-1-(4-chlorophenyl)-2-(phenyl)prop-2-en-1-one (43.3 mmol assumed) which was used directly in the next step. 1HNMR (CDCl3): δ 2.76 (s, 6H), 7.15 (m, 2H), 7.16-7.3 (m, 5H), 7.36 (m, 2H), 7.41 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07271266B2 |
| 出典データセット | uspto-grants-2007_09 |
| ORD ID | ord-d07aa8fd945d4302b79671bb3e436294 |
| 出典メモ | uspto-grants-2007_09 |