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Diethyl Ether → Methyl alpha-(2,6-diallyl-4-hydroxyphenoxy)4-chlorobenzeneacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Methyl 2-bromo-2-(4-chlorophenyl)acetate | HCID 10777987 | — |
| 反応物 | 2,6-Diallyl4-benzyloxyphenol | HCID 21985951 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl alpha-(2,6-diallyl-4-hydroxyphenoxy)4-chlorobenzeneacetate | HCID 21985939 | — |
反応手順
To a solution of 2,6-diallyl-4-benzyloxyphenol (200 mg, 1.0 eq) in DMF (8 mL) were added methyl α-bromo-4-chlorobenzeneacetate (190 mg, 1.0 eq) and Cs2CO3 (285 mg, 1.2 eq). The reaction mixture was stirred at room temperature for 15 h, poured into ether, washed with water and brine, dried over MgSO4, filtered, and concentrated in vac. Purification by chromatography (SiO2, EtOAc/Hexanes 1:20) afforded the desired methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091230B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-cbe90fa9d62e4ab79ebe977953f20624 |
| 出典メモ | uspto-grants-2006_08 |