Sodium Carbonate → 8-Amino-1-tetralone

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Carbonate	HCID 10340	—
反応物	Sodium Hydroxide	HCID 14798	—
反応物	N-(8-Oxo-5,6,7,8-tetrahydronaphthalen-1-YL)acetamide	HCID 12119265	—
溶媒	Hydrochloric Acid	HCID 313	—
生成物	8-Amino-1-tetralone	HCID 11400942	56%

反応手順

The amide (Intermediate J2, 4.12 g, 20.3 mmol) was heated at 90° C. in 6N HCl (140 mL) for 3 h. The mixture was cooled to rt and Na2CO3 was added in small portions followed by addition of 2N NaOH until the mixture was at pH 8. The aqueous layer was extracted with EtOAc and the organic fractions were combined, washed with brine, dried, filtered and concentrated to give 8-amino-3,4-dihydro-2H-naphthalen-1-one (Intermediate J3) as a dark red solid 1.82 g (56%).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07091232B2
出典データセット	uspto-grants-2006_08
ORD ID	ord-cb8706557d35427e999736d01fcd803a
出典メモ	uspto-grants-2006_08