化工社化工社 化学情報印刷レポート · 研究参考用
(Butylamino)acetonitrile → (RS)-N-butyl-4-chloro-N-(cyanomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Butylamino)acetonitrile | HCID 76373 | — |
| 反応物 | HCID 17990077 | HCID 17990077 | — |
| 生成物 | (RS)-N-butyl-4-chloro-N-(cyanomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide | HCID 90015777 | — |
反応手順
300 mg (1.12 mmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using (butylamino)acetonitrile to give after working up and purification 280 mg (69%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09296757B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-9388160c06b84dc1a83c39fb4d8b83b9 |
| 出典メモ | uspto-grants-2016_03 |