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4-Aminomethyltetrahydropyran → (7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| 反応物 | 7-Bromo-4-chloro-3-nitroquinoline | HCID 21984361 | — |
| 生成物 | (7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine | HCID 21984259 | 94.3% |
反応手順
The method described in Part E of Examples 431–436 was used to treat 7-bromo-4-chloro-3-nitroquinoline (12.43 g, 43.45 mmol) with C-(tetrahydropyran-4-yl)methylamine (10 g, 87 mmol) to provide 15.0 g of (7-bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine as a bright yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091214B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f146f725e49749349a288d4b0e2fcd92 |
| 出典メモ | uspto-grants-2006_08 |