関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Potassium Nitrate | HCID 24434 | — |
| 反応物 | Isoquinoline, 1-chloro- | HCID 140539 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 1-Chloro-5-nitroisoquinoline | HCID 459774 | — |
反応手順
A mixture of 1-chloroisoquinoline (6.0 g, 0.037 mol) in conc. H2SO4 (35 mL) was treated with a solution of fuming HNO3 (10 mL) and potassium nitrate (4.0 g, 0.040 mol) in conc. H2SO4 (35 mL) at 0-5° C. The mixture was stirred at 0° C. for a further 90 min, and poured into ice. The precipitate was collected, washed and dried to give the product as a yellow solid. LC-MS: 3.68 min, 209.2 & 211.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07312233B2 |
|---|
| 出典データセット | uspto-grants-2007_12 |
|---|
| ORD ID | ord-b5ac563706ea427f81b60b2abccc3ca5 |
|---|
| 出典メモ | uspto-grants-2007_12 |
|---|
