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N-Hydroxyphthalimide → N-(4-octyloxybenzyloxy)phthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Hydroxyphthalimide | HCID 10665 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | p-Octyloxybenzyl alcohol | HCID 144261 | — |
| 反応物 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(4-octyloxybenzyloxy)phthalimide | HCID 19969096 | 83.4% |
反応手順
Diethyl azodicarboxylate (18.4 g) was added dropwise to a suspension of 4-octyloxybenzyl alcohol (25 g), N-hydroxyphthalimide (17.15 g) and triphenylphosphine (27.74 g) in tetrahydrofuran (250 ml) under ice-cooling. The reaction mixture was stirred at room temperature for 2 hours, and evaporated in vacuo. The residue was purified by chromatography on silica gel to give N-(4-octyloxybenzyloxy)phthalimide (33.45 g) as crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USH0001638 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-e527255a53ed4f3889660a581d775414 |
| 出典メモ | uspto-grants-1997_03 |