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Potassium Carbonate → N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-(2-Chloroethyl)-1,2-dimethoxybenzene | HCID 3015359 | — |
| 反応物 | N-(3-pyrrolidyl)phthalimide hydrochloride | HCID 22926344 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide | HCID 15045352 | 11.3% |
反応手順
6.03 g of the hydrochloride was suspended into 100 ml of acetonitrile, to which 4.79 g of 2-(3,4-dimethoxyphenyl) ethyl chloride, 8.24 g of anhydrous potassium carbonate and n-tetrabutyl ammonium iodide (catalytic amount) were added and refluxed under heating for 20 hours. After allowing them to cool, the inorganic salts were filtered out and the solvent was distilled off. After adding ethyl acetate and washed with water, they were dried with anhydrous magnesium sulfate. The solvent was concentrated and purified on silica gel chromatography to obtain 1.03 g of the above-captioned compound (total yield: 6.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05607953 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-da22ce4dabb647e68b208ea118e2c094 |
| 出典メモ | uspto-grants-1997_03 |