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Cysteamine → Ethyl thiomorpholine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cysteamine | HCID 6058 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl 2,3-dibromopropionate | HCID 97945 | — |
| 反応物 | Toluene trichloromethane | HCID 22987606 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Ethyl thiomorpholine-3-carboxylate | HCID 13604869 | — |
反応手順
A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-dibromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05610120 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-cd7b7b6a0b964fdc88eeaf84aff66967 |
| 出典メモ | uspto-grants-1997_03 |