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3-Bromotoluene → 2-(3-Methylphenyl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromotoluene | HCID 11560 | — |
| 反応物 | 2-Bromobenzonitrile | HCID 16272 | — |
| 反応物 | HCID 178418306 | HCID 178418306 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 触媒 | HCID 178420538 | HCID 178420538 | — |
| 生成物 | 2-(3-Methylphenyl)benzonitrile | HCID 1394243 | 46.7% |
反応手順
3-Bromotoluene (17.5 mmoles, 3.0 g) was reacted with t-BuLi (19.3 moles) and ZnCl2 (19.3 mmoles, 2.62 g) followed by a Ni(PPh3)4 coupling to 2-bromobenzonitrile (17.5 mmole, 3.2 g) as in Preparation 1. The intermediate was purified by chromatography over silica gel eluted with 20% ether in hexane to yield 1.58 g of 2-(3-methylphenyl)-benzonitrile (MS)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05612360 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-9ccc724f711f4fd3835b9e850991d580 |
| 出典メモ | uspto-grants-1997_03 |