化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → N-[[(7-chloro-2,2,3,3-tetrafluorobenzothien-5-yl)amino]-carbonyl]-2-chlorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 2-Chlorobenzamide | HCID 69111 | — |
| 反応物 | 5-Amino-7-chloro-2,2,3,3-tetrafluoro-2,3-dihydrobenzothiophene | HCID 20222418 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-[[(7-chloro-2,2,3,3-tetrafluorobenzothien-5-yl)amino]-carbonyl]-2-chlorobenzamide | HCID 13785000 | 51.7% |
反応手順
In a manner similar to Step D of Example 1, the reaction of 0.58 g (0.0037 mole) 2-chlorobenzamide, 0.52 g (0.0051 mole) oxalyl chloride, 0.95 g (0.0037 mole) 5-amino-7-chloro-2,2,3,3-tetrafluoro-2,3-dihydrobenzothiophene, and 5 ml of methylene chloride in 75 ml of toluene produced 0.84 g of N-[[(7-chloro-2,2,3,3-tetrafluorobenzothien-5-yl)amino]-carbonyl]-2-chlorobenzamide as a solid (mp 140°-142° C.), compound 9 of Table 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04636523 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-478995f7001b4f6da4bccc09efe97d9c |
| 出典メモ | uspto-grants-1987_01 |