化工社化工社 化学情報印刷レポート · 研究参考用
Hexamethylphosphoramide → Bifonazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexamethylphosphoramide | HCID 12679 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | HCID 178419618 | HCID 178419618 | — |
| 生成物 | Bifonazole | HCID 2378 | 68.2% |
反応手順
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06870057B1 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-30e3f2394175491b9a9d832f7048cedb |
| 出典メモ | uspto-grants-2005_03 |