化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → Stavudine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 72016-54-7 | HCID 126354 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 反応物 | Dimesylthymidine | HCID 70036919 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Stavudine | HCID 18283 | 79% |
反応手順
In this synthesis, dimesylthymidine 1 was first treated with sodium hydroxide (3 equivalents) in refluxing water for 2 hours and after work-up the resultant 3,5-anhydrothymidine was treated with potassium t-butoxide in dimethylsulfoxide (DMSO) at room temperature for 2 hours. The reaction mixture was neutralized, evaporated to dryness and after a series of manipulations which included extraction, decolourization, precipitation and recrystallization, gave Stavudine in 79% yield and an overall yield of 56%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06635753B1 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-182aaade9989458b89f633f523d3aa88 |
| 出典メモ | uspto-grants-2003_10 |